Folates and Prevention of Neural-Tube Diseases
نویسندگان
چکیده
منابع مشابه
Is there more to folates than neural-tube defects?
The purpose of the present paper is to review our current understanding of the chemistry and biochemistry of folic acid and related folates, and to discuss their impact on public health beyond that already established in relation to neural-tube defects. Our understanding of the fascinating world of folates and C1 metabolism, and their role in health and disease, has come a long way since the di...
متن کاملFolates and prevention of disease.
Research in the past decade has established that low or inadequate folate status may contribute to congenital malformations and the development of chronic disease in later life. Using an evidence based approach, there are clear guidelines for recommending folic acid supplementation or fortification in certain disease conditions but further proof of its efficacy is required in other circumstance...
متن کاملNeural tube defects: prevalence, etiology and prevention.
Spina bifida and anencephaly, the common form of neural tube defects, affect approximately 300 000 newborns each year worldwide. The effectiveness of folic acid supplementation in preventing their occurrence or recurrence has been unambiguous since 1991. In general, the prevalence of these abnormalities has decreased in the past 20 to 30 years because of periconceptional folate supplementation,...
متن کاملStrategies for Prevention of Neural Tube Defects
Neural tube defects (NTDs) are congenital malformations of the brain and spinal cord caused by the failure of neural tubes to close between 21 and 28 days after conception (Sadler, 2005). Any disruption of neurulation during or prior to this time may result in a defect or failure of neural tube closure. Non-invasive prenatal diagnostic testing by ultrasound and maternal serum screening, which s...
متن کامل[Primary prevention of neural tube defects].
Neural tube defects (NTDs) are one of the commonest malformations seen in pediatric surgical practice.They form a spectrum of disease ranging from anencephaly to spina bifida occulta. NTDs are devastating conditions as most of the lesions (myelomeningoceles, myelocele etc.) are always associated with neurological deficits producing varying degree of limb paresis/paralysis, bladder and anorectal...
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ژورنال
عنوان ژورنال: Science Journal of Clinical Medicine
سال: 2013
ISSN: 2327-2724
DOI: 10.11648/j.sjcm.20130202.13